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How long does methylprednisolone stay in your system after taking? Medrol Dosepak (methylprednisolone) has a medium half life range of 18 to 36 hours - meaning it takes the body 18 to 36 hours to clear 50% of the drug from your plasma. For a drug to be totally eliminated from your system it takes around 5.5 times the half life.
What is comparable to prednisone? Prednisone and dexamethasone are synthetic (man-made) corticosteroids (steroids) used for suppressing the immune system and inflammation. These drugs have effects similar to other corticosteroids such as triamcinolone (Kenacort), methylprednisolone (Medrol), and prednisolone (Prelone).
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